[DENBA's wish]

As the declining birth rate becomes a national issue in our country DENBA wants to do its part to solve this problem through its technology.

Here are the figures from the Cabinet Office

Definition of fertility decline

A declining birth rate is defined as a total fertility rate (*) below 2.08, which is necessary to sustain the population.The total fertility rate (TFR) is one of the main indicators of population growth, showing the number of children born to women between the ages of 15 and 45 during their lifetime.

If this situation persists, it is said that the population will begin to decline in the future, which will have a negative impact on economic, social and other activities.The birth rate in Japan has been declining since the mid-1970s. Although various measures have been taken. However, Japan's population has now begun to decline after reaching a peak of 128.05 million in 2010.Japan's population is projected to fall to 86.74 million by 2060, a reduction of up to two-thirds from its peak within 50 years (*).

Reference: Cabinet Office, “Chapter 1: What is the status of fertility decline?

Joint research with the Jojo Women's Clinic

The results of a clinical study conducted in conjunction with the Jojo Women's Clinic (Takasaki City, Gunma Prefecture, Japan, President Takanori Jojo) showed that.The announcement was made as the damage caused by freezing and thawing of fertilized eggs (embryos) in infertility treatments can be minimized and the potential of the fertilized eggs can be maximized in the DENBA environment.

【Research results】

Pregnancy and delivery rates were compared in 546 cases (237 pre-introduction and 309 post-introduction) aged 25-46 years who underwent frozen-thawed embryo transfer one year before and one year after introduction, respectively.

Pregnancy and delivery rates in frozen-thawed embryo transfer

in the DENBA environment. Pregnancy and delivery rates were significantly improved in frozen-thawed embryo transfers.。

pregnancy rate 29.1%→38.5%

birth rate  14.3%→22.0%

Further application to embryo culture for fresh embryo transfer in in vitro fertilization (IVF-ET).

*Pregnancy and delivery outcomes of 300 in vitro fertilization (IVF-ET) cases performed between March and December 2022.

In Vitro Fertilization Fresh Embryo Transfer

In terms of pregnancy and delivery rates for IVF fresh embryo transfers, the Japanese Society of Obstetricians and Gynecologists also found a significant increase in both pregnancy and delivery rates since the publication date (2021).

pregnancy rate  21% → 54%

birth rate   15% → 29%


Commercialization of the proprietary incubator is underway, based on joint research with the Jojo Women's Clinic.The launch is planned for the second half of 2024. Thank you for your continued support.

Jojo Women's Clinic

534-1 Kurisaki-cho, Takasaki-shi, Gunma Prefecture

President: Takanori Kamijo


The Shangmao News, released on April 21, 2024, published a report on the increased delivery rate of infertility treatment in vitro fertilization. Please make sure to read it.